Although Liverpool's victory over Manchester City in the quarter-finals of the Champions League may have been deemed an underdog victory by some, the big story on Tuesday night was Roma producing a stunning comeback to knock Barcelona out of the competition.
Barca were heavy favourites to progress after a 4-1 first-leg win at the Nou Camp, but fell apart to Roma's brilliant showing at the Stadio Olimpico as the Giallorossi levelled the tie to 4-4 with a 3-0 win and progressed on away goals.
Edin Dzeko struck early to give Roma hope and Daniele de Rossi added a second-half penalty, before defender Kostas Manolas scored the crucial third goal, heading in at the near post with eight minutes remaining.
Football Manics takes a look at some of the post-match reaction from a historic night in the Eternal City.
Ernesto Valverde, Barcelona head coach
"We had no response, everything went for them and for us we struggled to build our play.
"I am responsible absolutely; I am the visible head of the team and it was down to me. With their pressure it forced us to knock balls long, we became disjointed and we were not able to win the second ball.
"When you lose and the opposition are better then the analysis is often extreme. They were strong, physical and we had a lot of problems. Seasons are long and to win a competition is not easy, with only one winning.
"We know how disappointing this will be for the fans and us, we wanted to play a semi final, this is football. Everyone is now affected by this but we need to bounce back because we have two competitions that we want to win."
Josep Maria Bartomeu, Barcelona president
"I'm really sorry. Roma were the better team on the pitch. Roma believed and showed that when you try hard, you can achieve your objectives.
"Of course [this defeat] affects us, but we have some important games coming up and the players will recover. This team are always prepared to win on all fronts, be it with Ernesto Valverde or another coach.
"We fight to win everything every season, but tonight it wasn't to be."
Sergio Busquets, Barcelona midfielder
"It's a very tough night, a sad night and one to forget. We need to apologise to the fans for how we have fallen. This is the toughest blow I've received in the whole time I've been at Barca because of how it happened.
"I would be lying if I said we could use this as a learning experience because last year we went out in a similar way. Our results in Europe in the last two years have been very bad; we have to change things if we want to win the Champions League again."
Andres Iniesta, Barcelona midfielder
"That is a possibility (the game being his last in the Champions League) and for that reason it hurts even more. It's a very hurtful elimination because nobody expected it due to the lead we had.
"When you do things badly, make lots of mistakes and don't adapt to the game, this is what happens. It's a big disappointment because of the season we were having. It's difficult to take this elimination because we had a lot of hope and it has escaped."
Eusebio Di Francesco, Roma head coach
"I take the blame for defeats and some ungrateful words on social media, so I may as well take the credit for a win.
"The truth is that I made this choice to create more width, allow more counter-attacks and bring speed, but what really changed was the philosophy of the side and we have to continue like this now.
"Although we have had very good performances in Serie A, we are only now reaping the rewards -- the just rewards -- for the hard work we have done."
Daniele De Rossi, Roma captain
“What a night. This is a great result for us and for our history. The important thing is that we continue like this. We haven’t accomplished anything yet as there are still many games to go. Even if we lost the first-leg game, we were confident with the way we had played and it showed tonight.
“The difference for me was Di Francesco as he helped us play the right way. He changed a lot of things and he got it spot on. I am happy for the coaches and for my team-mates. We did great. This is also very important for me too as I am 34 years old. This win is one of the best I have ever experienced since joining Roma.”
Alessandro Florenzi, Roma midfielder
“To be honest, we never really felt it was at risk tonight, as Barcelona did nothing to cause us problems. We put in the perfect performance.
“Tactically, we were a step above them. If Barcelona don’t get to play the ball to feet and pass it around comfortably, they really struggle.”
Edin Dzeko, Roma striker
"It wasn't easy, but I stayed here and am very happy to be here. I think the club is glad, too. Let's not talk about [the move]. Money doesn't matter.
"This was the best, but even better may well be yet to come. It proved we can play against anyone, as Barcelona are such a strong side. We put three goals past them and could have had more.
"I have never seen Barcelona struggle so much. We pressed them constantly from the first minute."
Jurgen Klopp, Liverpool manager
"I walked up the stairs and someone told me. I thought it was a joke. Not that I don't respect Roma, they are fantastic team. I just wasn't expecting it, but knew it was possible.
"They lost Mo Salah and they are in the semis - it's a big thing! This competition is quite fair and I really think a normal final would have been Manchester City against Barcelona, and now they are both out.
"But there will still be two other really strong teams in there plus Roma and us. We will see what happens but that's not the thing I have to think about right now."