Manchester United and Sevilla meet at Old Trafford on Tuesday night with the last-16 tie delicately poised at 0-0.
Can the Red Devils finish the job? Football Manics previews the action.
The first leg three weeks ago was the first time that United and Sevilla had met in competitive action as David de Gea's heroics in Andalusia helped the Red Devils secure a goalless draw.
Tuesday's game will be the first time that Sevilla have visited Old Trafford for a competitive European fixture, although they did take part in Rio Ferdinand's testimonial back in August 2013, winning 3-1.
Over the years, 21 out of 30 away sides who draw the first leg of a Champions League knockout tie 0-0 end up progressing to the next round.
United have largely struggled against teams from Spain in Europe, winning just 13 of their previous 51 games.
However, they have only lost one of their past nine home Champions League games against Spanish sides - against Real Madrid at this stage in 2012-13.
The Red Devils have not managed to score more than one goal in any of their past 15 Champions League encounters with Spanish opposition (seven goals in total).
Mourinho has only lost seven of his previous 69 Champions League home games as manager, though five of those were against Spanish teams.
Standings and form
United go into this game on the back of a run of three consecutive wins in the Premier League, coming from behind beat both Chelsea and Crystal Palace before seeing off Liverpool 2-1 on Saturday to cement second place in the league. Their home form is excellent, having won all five games at Old Trafford in all competitions so far in 2018 and having only lost to Manchester City in 20 home games this season.
Sevilla, meanwhile, currently sit fifth in La Liga, one place worse off than where they finished last season. Since playing United three weeks ago, they have lost one and won two of their three league matches. A 5-2 defeat at home to Atletico Madrid was followed up with a 1-0 away win over Malaga and a 2-0 victory against Athletic Bilbao.
Manchester United record signing Paul Pogba has returned to training after missing Saturday's 2-1 Premier League victory over Liverpool but Jose Mourinho is unsure whether he will feature.
Forward Anthony Martial could return at Old Trafford after missing two matches but defenders Phil Jones, Marcos Rojo and Daley Blind, will be sidelined alongside midfielder Ander Herrera.
Tuesday's game could also come too soon for striker Zlatan Ibrahimovic, who is regaining fitness after almost three months out with a knee injury.
Midfielder Michael Carrick will hope to be included after confirming on Monday that he will retire at the end of the season.
Sevilla will be without defender Sebastien Corchia, while Daniel Carrico is also a doubt, and former Manchester City winger Jesus Navas is unlikely to make the squad as he recovers from injury.
All the signs seem to point to a Man United victory - they are in good form at present, have only lost once at Old Trafford all season (to a vintage Manchester City side) and Sevilla, who are struggling to put away Spain's bigger sides this term, have never won a Champions League game in England. If anybody knows how to contain an opponent and claim just enough for victory, it is Jose Mourinho.
Score prediction: United 1-0 Sevilla (United go through 1-0 on aggregate)